Sr. Advisor / Director - Analytical Chemistry - Discovery Chemistry Research & Technologies

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: April 6, 2025

Job Description:

Analytical Chemistry - Discovery Chemistry Research & TechnologiesAnalytical Chemistry - Discovery Chemistry Research & TechnologiesApply locations US, Indianapolis IN time type Full time posted on Posted 4 Days Ago job requisition id R-79257At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $121,500 - $198,000.The Discovery Chemistry Research & Technologies organization within Lilly Research Laboratories (LRL) is seeking an Analytical Purification Scientist with expertise in supercritical fluid, normal phase, and reverse phase chromatography to join the Analytical Sciences group within Medicinal Chemistry located at Lilly Corporate Center, Indianapolis, IN. The candidate will act as a lead scientist to execute compound purification on milligram to gram scale using an array of analytical and preparative purification techniques and provide innovative solutions to complex analytical and separation problems to accelerate the small molecule discovery portfolio.Responsibilities:

• Always keep safety as the top priority, striving to maintain a proactive safety culture.
• Work across all areas of achiral and chiral purification modes including normal phase, reverse phase, and SFC, crude sample analysis, method selection and optimization, and material quality control.
• Use their scientific knowledge and experience of various analytical techniques to solve diverse problems, develop purification methods, evaluate and implement new analytical technologies and methods, and influence purification strategy at project, team, and departmental levels.
• Be able to establish strong collaboration and partnerships with portfolio project teams to provide technical guidance to solve analytical and purification problems to allow for rapid iteration through design cycles.
• Work in close collaboration with internal and external partners to ensure a strong relationship and rapid delivery of quality results in a format customized to meet their specific needs.
• Maintain a high level of productivity in the laboratory setting.
• Work to support and enhance analytical and small scale-preparative purification capabilities for high-throughput chemistry experimentation and library synthesis.
• Collaborate with late-stage discovery projects to facilitate large-scale purifications.
• Be responsible for purification instruments, providing basic troubleshooting and partnering with groups for support.
• Mentor and develop scientific staff. Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.
• Keep abreast of current literature and industry trends to assess new approaches in purification and analytical technologies.
• Strong attention to detail and the ability to manage several projects simultaneously.
• Contribute to Lilly Research Lab-wide initiatives embracing diversity of thought, background, and experience to deliver creative solutions in the face of ambiguity.
• Enthusiastic and self-motivated, with excellent communication skills necessary to operate effectively in a fast-paced multidisciplinary environment with flexibility and an adaptable approach to goal delivery.
• Demonstrate strong written and verbal communication skills to represent both the technical aspects and business-related implications of your work.Qualifications:Minimum Qualifications:
  • Ph.D. in analytical chemistry, or a closely related field with 2+ years of experience in the pharmaceutical industry, or alternatively a B.S./M.S. in chemistry with 10+ years of experience in the pharmaceutical industry.
    • Proven hands-on experience in analysis and purification of organic molecules in an industrial or academic setting working with various purification techniques including chromatography (HPLC, SFC, GC, LC-MS), crystallization.
    • Extensive theoretical knowledge of (U)HPLC and SFC chromatography and method development.
    • Proven hands-on experience with milligram, gram, and kilogram scale purification.
    • Proven hands-on experience running and interpreting data from (U)HPLCMS and SFCMS instruments.
    • Excellent English communication skills (verbal and written).Additional Desired Skills:
      • Experience with instrument maintenance.
      • Proven hands-on experience with analytical and preparative Agilent, Shimadzu, and/or Teledyne (U)HPLC and SFC systems.
      • Familiarity with a variety of assays such as stability, racemization or forced degradation.
      • Experience with GC-MS.
      • Experience with programming, automation, and data management. Experience with model generation and predictive methods is a plus.
      • Experience working with and implementing AI/ML into analytical purification workflows.
      • Experience with a variety of sample drying equipment, such as Genevac Rocket Synergy 2 and EZ-2, Biotage V10 evaporators, and lyophilizers.
      • Learning agility and demonstrated ability to apply technical knowledge to improve the understanding of chemical systems or improve analytical techniques.
      • Demonstrated ability to balance multiple activities, prioritize evolving project needs, and handle ambiguity.Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.#WeAreLilly
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